Compazine: What It Is, How It Works, and What to Watch For

If you’ve been prescribed Compazine, you’re probably wondering why your doctor chose it and what you should expect. Compazine is the brand name for prochlorperazine, a medication that belongs to the phenothiazine class. It’s most commonly used to treat severe nausea, vomiting, and dizziness, but doctors also prescribe it for certain psychotic disorders.

How does it actually calm your stomach? Prochlorperazine blocks dopamine receptors in the brain’s chemoreceptor trigger zone, which reduces the urge to vomit. The same dopamine‑blocking action also helps settle symptoms of schizophrenia and other psychotic conditions. Because it works on the brain, you’ll feel the effect fairly quickly—usually within 30 minutes for nausea relief.

Typical Doses and How to Take Compazine

Compazine comes in tablets, oral solution, and injectable forms. For nausea, adults often start with 5 mg by mouth every 6‑8 hours. Your doctor might adjust the dose based on how well you respond and any side effects you notice. If you’re using it for psychosis, the dose can be higher, sometimes up to 20 mg per day split into several doses.

Never crush the tablets unless your doctor says so. The oral solution is handy if you have trouble swallowing, but it still contains the same amount of medication per milliliter. Follow the exact schedule your prescriber gave you—missing doses can make your symptoms flare up again.

Common Side Effects You Should Know

Like any drug that messes with dopamine, Compazine can cause side effects. The most frequent ones are drowsiness, dry mouth, and dizziness. Some people notice light‑headedness when they stand up quickly, so get up slowly to avoid falls.

More serious reactions—though rare—include muscle stiffness, tremors, and unexplained fever. If you develop a high fever, stiff neck, or muscle pain, seek medical help right away; these could be signs of a serious condition called neuroleptic malignant syndrome.

Eye problems such as blurred vision or difficulty focusing can also happen. If you wear glasses, you might need to adjust your prescription temporarily.

Pregnant or nursing women should discuss risks with their doctor. Compazine crosses the placenta, and while it’s not outright banned, the benefits must outweigh potential risks to the baby.

Alcohol and other sedatives amplify drowsiness, so avoid them unless your doctor clears it.

Buying Compazine Safely Online

Because Compazine is prescription‑only, you’ll need a valid doctor’s order to purchase it. Look for online pharmacies that require a prescription, display a licensed pharmacist, and have secure HTTPS connections.

Beware of sites that offer “no‑prescription” Compazine for unbelievably low prices—they’re often selling counterfeit or unsafe products. Check for certifications like CIPA (Canadian International Pharmacy Association) or NABP (National Association of Boards of Pharmacy) if you’re ordering from abroad.

Compare prices, but don’t let a bargain override safety. A reputable pharmacy will also provide clear dosage instructions, expiration dates, and a way to contact a pharmacist with questions.

If you’re in the US, you can use services like GoodRx to find local pharmacies with the best price and then pick up the medication in person. This avoids shipping delays and lets you verify the product right away.

Finally, always store Compazine at room temperature, away from moisture and heat. Keep it out of reach of children, and discard any pills that look discolored or crumble.

Compazine can be a lifesaver for nausea and a useful tool for certain mental health conditions when used correctly. By understanding the right dose, watching for side effects, and buying from a trusted source, you’ll get the most benefit with the least hassle.